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Oxidative stress in Systemic Sclerosis.

G Simonini1, M M Cerinic, S Generini

  • 1Department of Pediatrics, University of Florence, Italy.

Molecular and Cellular Biochemistry
|August 17, 1999
PubMed
Summary
This summary is machine-generated.

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Systemic Sclerosis (SSc) patients exhibit elevated levels of oxidative stress markers, including diene-conjugates and antibodies against oxidized low-density lipoproteins. These markers are particularly high in early disease stages and the limited SSc subset, suggesting a role in disease pathogenesis.

Area of Science:

  • Biochemistry
  • Immunology
  • Rheumatology

Background:

  • Systemic Sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis and vascular abnormalities.
  • Oxidative stress is implicated in the pathogenesis of various chronic diseases, including autoimmune conditions.

Purpose of the Study:

  • To investigate the levels of peroxidation product diene-conjugates (DC) and antibodies against oxidized low-density lipoproteins (Ab oxLDL) in patients with Systemic Sclerosis.
  • To compare these oxidative stress markers between different subsets and stages of SSc and healthy controls.

Main Methods:

  • Serum samples from 63 SSc patients (limited and diffuse subsets; early and advanced stages) and 21 healthy controls were analyzed.
  • Diene-conjugates (DC) were measured spectrophotometrically (absorbance 234 nm).

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  • Antibodies against oxidized low-density lipoproteins (Ab oxLDL) were quantified using a standard ELISA.

    • Main Results:

    • DC levels were significantly higher in SSc patients compared to controls, and also higher in the limited and early SSc subsets.
    • Ab oxLDL levels were significantly elevated in SSc patients across all subsets and stages compared to controls.
    • Higher levels of both DC and Ab oxLDL were observed in the early stages and limited subset of SSc.

    Conclusions:

    • The study demonstrates increased oxidative stress in Systemic Sclerosis patients, indicated by elevated DC and Ab oxLDL levels.
    • These oxidative stress markers appear to play a significant role in the pathogenesis and tissue damage observed in SSc, particularly in early and limited disease forms.
    • The findings suggest that oxidative stress, possibly linked to reperfusion episodes in Raynaud's phenomenon, contributes to microvascular damage in SSc.