Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dendritic cells in genetic immunization.

A Takashima1, A Morita

  • 1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235-9069, USA.

Journal of Leukocyte Biology
|August 17, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and impact of solar lentigines: An international survey.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Patterns of regret for inadequate sun protection: A population-based study [HELIOS].

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Subcutaneous pedicle subunit flap for upper lip reconstruction.

JPRAS open·2025
Same author

Attitudes and behaviors regarding sun exposure in Japan compared to Europe and North America.

The Journal of dermatology·2024
Same author

Do regrets of parents about sun overexposure impact preventive measures applied on their children?

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Stimulating peristalsis improves esophagogastric junction observation during sedated esophagogastroduodenoscopy in children and adolescents.

Acta gastro-enterologica Belgica·2022

Genetic immunization using plasmid DNA induces immune responses against pathogens and tumors. New technologies enhance genetic vaccination efficacy and control immune responses, involving dendritic cells (DC).

Area of Science:

  • Immunology
  • Vaccinology
  • Molecular Biology

Background:

  • Genetic immunization, using naked plasmid DNA, elicits humoral and cellular immune responses.
  • This vaccination method has shown promise in inducing protective immunity against pathogens and tumors in animal models.
  • Dendritic cells (DC) are crucial, potentially mediating antigen presentation through MHC class II, MHC class I cross-presentation, or direct presentation by transfected DCs.

Purpose of the Study:

  • To provide an overview of recent technological advancements in genetic immunization.
  • To discuss strategies for improving the efficacy of genetic vaccination.
  • To explore methods for regulating the type and class of immune responses generated by genetic immunization.

Main Methods:

  • Review of emerging technologies in genetic immunization.

Related Experiment Videos

  • Analysis of modifications to plasmid DNA for enhanced immunogenicity.
  • Examination of co-delivery strategies with immunoregulatory genes.
  • Discussion of dendritic cell (DC) targeting approaches.

    • Main Results:

    • Genetic immunization effectively induces both humoral and cellular immunity.
    • Dendritic cells play multifaceted roles in antigen presentation during genetic immunization.
    • New technologies aim to optimize genetic vaccination outcomes.

    Conclusions:

    • Genetic immunization is a potent vaccination strategy with broad applications.
    • Advancements in plasmid DNA modification, gene co-delivery, and DC targeting are improving genetic vaccination.
    • These innovations offer greater control over immune responses for enhanced therapeutic and prophylactic benefits.