Polarity in early mammalian development

Although overall polarity is discernable morphologically in both the growing and mature oocyte in mammals, it is typically relatively inconspicuous in the zygote. Furthermore, the conceptus exhibits an essentially radial organization during cleavage which was long held to persist until the primitive streak forms at the onset of gastrulation. This view has been challenged by various recent studies which clearly show that asymmetries are evident both morphologically and at the molecular level from very early in development. Collectively, these new findings argue that specification of the anterior-posterior axis of the fetus depends on information that is localized extra-embryonically in cells which begin to differentiate before the conceptus implants in the uterus.