Related Experiment Video
Updated: Aug 15, 2026

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
Published on: December 14, 2015
Extracellular modulation of the Hedgehog, Wnt and TGF-beta signalling pathways during embryonic development
J Capdevila1, J C lzpisúa Belmonte
1The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Abstract:
Localized embryonic expression of members of the Hedgehog, Wnt and TGF-beta families of secreted factors has been shown to organize pattern and provide positional information in many developing systems. Recently, several extracellular factors have been described that act either as facilitators or inhibitors of the activities of those secreted proteins. The variety of molecular strategies involved in the extracellular modulation of signalling activities in the embryo underscores the importance of maintaining a tight spatial and temporal control of the activities of organizing centers during development.
More Related Videos
11:48Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression
Published on: January 17, 2016
07:34The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
Published on: February 16, 2017
Related Concept Videos
Notch Signaling Pathway
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Canonical Wnt Signaling Pathway
Hedgehog Signaling Pathway
Non-Canonical Wnt Signaling Pathways
Non-Canonical Wnt Signaling Pathways
Hedgehog Signaling Pathway