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Related Experiment Videos

Anaplastic thyroid carcinoma survival.

P E Voutilainen1, M Multanen, R K Haapiainen

  • 1Second Department of Surgery, Helsinki University Central Hospital, Box 260, FIN-00029 HUCH, Helsinki, Finland.

World Journal of Surgery
|August 18, 1999
PubMed
Summary
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Long term prognosis of medullary thyroid carcinoma in 39 patients.

Annales chirurgiae et gynaecologiae·2001

Anaplastic thyroid carcinoma is a rare, aggressive cancer. Key prognostic factors include resectability and metastases, but survival remains poor despite interventions.

Area of Science:

  • Oncology
  • Endocrinology
  • Surgical Pathology

Background:

  • Anaplastic thyroid carcinoma (ATC) is a rare, aggressive malignancy predominantly affecting elderly individuals.
  • ATC is characterized by rapid progression and poor patient outcomes.

Purpose of the Study:

  • To characterize the patient population diagnosed with anaplastic thyroid carcinoma.
  • To identify potential subgroups with improved prognosis or beneficial interventions for ATC.

Main Methods:

  • Retrospective analysis of 33 patients with ATC treated between 1967 and 1994.
  • Survival analysis using the product limit method and Cox proportional hazards regression.

Main Results:

  • The 1-year disease-specific survival rate was 9.7%.

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  • Independent prognostic factors identified: local resectability, absence of distant metastases at diagnosis, radiotherapy, and radioiodine ablation.
  • Only one patient, with a focus of ATC within a follicular carcinoma, survived.

    • Conclusions:

    • Despite identifying statistically significant prognostic factors, patient survival for anaplastic thyroid carcinoma remains poor.
    • Current surgical interventions appear insufficient for treating symptomatic ATC.