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Low density lipoprotein (LDL) modification: basic concepts and relationship to atherosclerosis.
A Sevanian1, L Asatryan, O Ziouzenkova
1Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, Calif 90033, USA. asevan@hsc.usc.edu
Blood Purification
|August 18, 1999
Summary
Electronegatively modified LDL (LDL(-)) contributes to atherosclerosis risk, especially in dialysis patients. A novel haemolipodialysis (HLD) method effectively reduces LDL(-) formation during hemodialysis.
Area of Science:
- Biochemistry
- Cardiovascular Science
- Nephrology
Background:
- Atherosclerosis risk is linked to LDL subfractions.
- Electronegatively modified LDL (LDL(-)) is more atherogenic and susceptible to oxidation.
- Elevated LDL(-) is observed in coronary artery disease, diabetes, and hemodialysis (HD) patients.
Purpose of the Study:
- To investigate the formation of LDL(-) during HD.
- To evaluate the efficacy of haemolipodialysis (HLD) in reducing LDL(-) formation.
Main Methods:
- Isolation and characterization of LDL subfractions.
- In vitro studies using a model HD system.
- Comparison of standard HD with HLD using antioxidants (vitamins E and C).
Main Results:
- Standard HD promotes rapid LDL(-) formation.
- HLD significantly reduces LDL(-) formation compared to standard HD.
- HLD delivers antioxidants locally at supra-physiological levels.
Conclusions:
- LDL(-) formation during HD may involve protein-radical interactions.
- HLD is a promising approach to mitigate atherosclerosis progression in HD patients.
- HLD appears more effective than oral antioxidant supplementation.