Synthesis of certain new 2,4,5(6) trisubstituted-1,2,4-triazolo[1,5-alpha]pyrimidines as potential antihypertensive agents
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Updated: Oct 19, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
S M Bayomi1, A M Abdelal, S M el-Ashry
1Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
Abstract:
A series of 1,2,4-triazolol[1,5-alpha]pyrimidines bearing at position 2, morpholine, piperidine or piperazine moities has been prepared. In addition, ethyl 4-methyl-2-(4-acylpiperazin-1-yl)-1,2,4-triazolo[1, 5-alpha]pyrimidin-7(4H)-one-6-carboxylates 25,26, which have related structure with prazosin, have been synthesized. Ten representative compounds were tested in vitro and in vivo for their antihypertensive activity where compounds 7, 11 and 25 showed promising activity. The detailed synthesis, spectroscopic and biological data are reported.
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