Related Experiment Videos
Telomerase expression in intracranial tumours: prognostic potential for malignant gliomas and meningiomas
M L Falchetti1, R Pallini, L M Larocca
1Istituto di Medicina Sperimentale, CNR, Rome, Italy.
Journal of Clinical Pathology
|August 18, 1999
Abstract
Aim:
To evaluate the diagnostic value of telomerase expression in intracranial tumours.
Methods:
98 surgical specimens from different neoplasms were analysed by the telomeric repeat amplification protocol (TRAP) and the presence of telomerase compared with the histological diagnosis and the proliferation index.
Results:
A high degree of positivity for telomerase activity was found in glioblastomas and atypical/anaplastic meningiomas. Telomerase activity was poorly detected in anaplastic astrocytomas.
Conclusions:
The TRAP assay seems to be a valuable index for identifying meningeal tumours with aggressive behaviour.