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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

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Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
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Published on: May 2, 2017

Optimization of urinary FDG excretion during PET imaging.

J K Moran1, H B Lee, M D Blaufox

  • 1Department of Nuclear Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|August 18, 1999
PubMed
Summary

Fluorodeoxyglucose (FDG) accumulation in urine can obscure PET imaging. Hydration increases FDG excretion, but diuretics may offer a better way to manage urinary activity without increasing FDG delivery to the bladder.

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Area of Science:

  • Nuclear Medicine
  • Radiopharmacology
  • Renal Physiology

Background:

  • Urinary fluorodeoxyglucose (FDG) accumulation poses a significant challenge in Positron Emission Tomography (PET) imaging, often obscuring visualization of pelvic and abdominal structures.
  • Limited data exists on physiological factors influencing FDG urinary excretion, hindering efforts to minimize this interference during PET scans.

Purpose of the Study:

  • To investigate physiological variables affecting FDG urinary excretion.
  • To evaluate the impact of hydration and diuretic treatment on FDG excretion in both animal models and human subjects undergoing PET imaging.

Main Methods:

  • FDG urinary excretion was measured in rats under normal, hydrated, hydrochlorothiazide-treated, and phlorizin-treated conditions.
  • FDG clearance rates were compared to glomerular filtration rates in rats.
  • FDG excretion was assessed in hydrated and dehydrated human patients undergoing PET scans.

Main Results:

  • Hydrated and phlorizin-treated rats exhibited the highest FDG excretion.
  • Hydrochlorothiazide increased urine volume but not FDG excretion percentage.
  • Hydrated patients showed significantly higher FDG excretion and urine volume compared to dehydrated patients.

Conclusions:

  • Hydrochlorothiazide increases urine volume but does not enhance FDG excretion.
  • Patient hydration before PET scanning increases FDG delivery to the bladder.
  • Diuretics may be a preferable method for increasing urinary volume without augmenting FDG delivery to the bladder.