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Positron emission tomography in juvenile Alexander disease
Y Sawaishi1, J Hatazawa, N Ochi
1Department of Pediatrics, Akita University School of Medicine, Japan. sawaishi@med.akita-u.ac.jp
Abstract:
A 13-year-old boy with cervical kyphosis was diagnosed as having juvenile Alexander disease because of the typical MRI findings, abnormally elevated alphaB-crystallin and heat shock protein 27 in the cerebrospinal fluid. Positron emission tomography with 18F-fluorodeoxyglucose demonstrated hypometabolism in the frontal white matter corresponding to the areas with leukodystrophy. However, the overlying gray matter preserved normal glucose metabolism.
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