Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cherubism: clinicopathologic features.

T Yamaguchi1, H D Dorfman, S Eisig

  • 1Department of Orthopaedic Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10467-2490, USA.

Skeletal Radiology
|August 18, 1999
PubMed
Summary

This case report details cherubism in a 6-year-old boy, highlighting its distinct jaw enlargement and facial features. Histological findings confirm it is indistinguishable from giant-cell reparative granuloma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brown tumors developing in renal transplant recipients with persistent hyperparathyroidism: two case reports and review of literature.

Clinical nephrology·2004
Same author

Recurrent chondromyxoid fibroma of the thoracic spine 30 years after primary excision: case report and review of the literature.

International journal of surgical pathology·2003
Same author

Giant cell reparative granuloma: a comparative clinicopathologic study of lesions in gnathic and extragnathic sites.

International journal of surgical pathology·2001
Same author

Sarcomatous transformation of the orbit in a patient with Paget's disease.

Ophthalmology·2000
Same author

t(X;4)(q22;q31.3) in giant cell reparative granuloma.

Cancer genetics and cytogenetics·1999
Same author

Synovial desmoplastic fibroblastoma of hip joint with bone erosion.

Skeletal radiology·1999

Area of Science:

  • Oral and Maxillofacial Surgery
  • Pediatric Dentistry
  • Genetics

Background:

  • Cherubism is a rare genetic disorder characterized by progressive, bilateral, symmetrical enlargement of the jaw.
  • Early diagnosis and understanding of its histological characteristics are crucial for management.

Observation:

  • A 6-year-old boy presented with significant bilateral jaw enlargement.
  • Associated features included medially dislocated premature teeth, a narrow V-shaped palate, and mild upward-slanting eyes.
  • Radiographs revealed multiloculated osteolytic lesions in the mandible and maxilla.

Findings:

  • Histopathological examination showed a non-neoplastic fibrous lesion.
  • The lesion was rich in multinucleated giant cells, consistent with giant-cell reparative granuloma.
  • Cherubism is histologically indistinguishable from giant-cell reparative granuloma, despite historical debate.

Implications:

  • This case reinforces the importance of accurate histological diagnosis in managing cherubism.
  • Understanding the histological similarity to giant-cell reparative granuloma aids in differentiating it from other jaw pathologies.
  • Further research into the genetic basis and optimal treatment strategies for cherubism is warranted.

Related Experiment Videos