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Discovery of a highly potent, functionally-selective muscarinic M1 agonist, WAY-132983 using rational drug design and
A L Sabb1, G M Husbands, J Tokolics
1Wyeth-Ayerst Research, Princeton, NJ 08543-8000, USA.
Bioorganic & Medicinal Chemistry Letters
|August 18, 1999
Abstract:
Rational drug design utilizing a receptor homology model of the human muscarinic M1 receptor led to the discovery of the highly potent (Ki = 2 nM), efficacious, and in vivo functionally-selective M1 agonist, WAY-132983.