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Lobophorins A and B, new antiinflammatory macrolides produced by a tropical marine bacterium
Z D Jiang1, P R Jensen, W Fenical
1Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0236, USA.
Bioorganic & Medicinal Chemistry Letters
|August 18, 1999
Abstract:
Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent inhibitors of topical PMA-induced edema in the mouse ear assay when administered either topically or IP.