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C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study
M T Goulet1, P J Sinclair, F Wong
1Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
Abstract:
A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.
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