Related Experiment Video

Updated: Jul 29, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Chronic sternal wound infection and endocarditis with Coxiella burnetii

M Ghassemi1, W A Agger, R E Vanscoy

  • 1Department of Medical Education, Gundersen-Lutheran Medical Foundation, La Crosse, Wisconsin, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|August 18, 1999
PubMed

Insights

Chronic Q fever, often linked to heart infections, can also cause persistent wound issues. This case highlights Coxiella burnetii

Area of Science:

  • Infectious Diseases
  • Rheumatology
  • Immunology

Background:

  • Chronic Q fever commonly presents as culture-negative endocarditis.
  • Other manifestations include vascular graft infections, hepatitis, and neurological issues.

Observation:

  • A patient presented with chronic sternal wound infection, polyclonal gammopathy, and mixed cryoglobulinemia.
  • Q fever endocarditis was diagnosed and confirmed by Coxiella burnetii DNA in wound tissue.

Findings:

  • Polymerase chain reaction confirmed Coxiella burnetii DNA in the sternal wound.
  • Successful treatment of Q fever endocarditis led to rapid wound healing.

Implications:

  • Chronic Q fever can manifest without typical exposure risks.
  • It can lead to multisystem inflammation and immune system dysfunction.
  • Persistent wound infections may be an unrecognized presentation of chronic Q fever.

More Related Videos

Generation and Multi-phenotypic High-content Screening of Coxiella burnetii Transposon Mutants11:44

Generation and Multi-phenotypic High-content Screening of Coxiella burnetii Transposon Mutants

Published on: May 13, 2015

Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing10:29

Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing

Published on: July 6, 2016

Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...