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Decrease of serum endothelin levels with postmenopausal hormone replacement therapy or tibolone.

W Haenggi1, N A Bersinger, M D Mueller

  • 1Department of Obstetrics and Gynecology, University of Berne, Switzerland.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|August 19, 1999
PubMed
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Hormone replacement therapy (HRT) significantly lowers endothelin levels in postmenopausal women. Tibolone demonstrated comparable endothelin reduction to estrogen-based HRT, suggesting cardioprotective benefits.

Area of Science:

  • Cardiovascular Endocrinology
  • Pharmacology
  • Menopausal Health

Background:

  • Endothelin is a potent vasoconstrictor.
  • Estrogen-based hormone replacement therapy (HRT) is known to reduce endothelin levels.
  • Postmenopausal women often experience hormonal changes affecting cardiovascular markers.

Purpose of the Study:

  • To investigate the effect of tibolone and different estrogen formulations on plasma endothelin levels in postmenopausal women.
  • To compare the efficacy of tibolone with conventional HRT in modulating endothelin.

Main Methods:

  • A randomized controlled trial involving 51 postmenopausal women.
  • Measurement of plasma endothelin levels before and after 24 months of HRT.
  • Treatment groups included oral tibolone, oral 17 beta-estradiol, and transdermal 17 beta-estradiol.

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  • A control group of comparable volunteers was included.

    • Main Results:

    • Endothelin levels decreased by 18.2% with tibolone, 23.1% with oral estradiol, and 20.8% with transdermal estradiol after 24 months.
    • Endothelin levels increased by 36.6% in the control group (p < 0.01).
    • Tibolone showed a similar reduction in endothelin levels compared to estrogen-progestogen-replacement therapy.

    Conclusions:

    • Tibolone effectively reduces endothelin levels in postmenopausal women.
    • The reduction is comparable to conventional estrogen-based HRT.
    • These findings suggest a potential mechanism for the cardioprotective effects of tibolone.