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[A clinical study of early enteral feeding to protect the gut function in burned patients]

S Wang1, S Wang, A Li

  • 1Department of Surgery, 47th Army Hospital of People's Liberation Army, Chengdu.

Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi = Zhonghua Zheng Xing Shao Shang Waikf [I.E. Waike] Zazhi = Chinese Journal of Plastic Surgery and Burns
|July 1, 1997
PubMed

Insights

Early enteral feeding in burn patients significantly reduces plasma endotoxin and MDA levels, mitigating gut injury. This approach helps decrease inflammatory mediators, improving outcomes after severe burns.

Area of Science:

  • Burn injury research
  • Gastrointestinal physiology
  • Inflammatory response

Background:

  • Burn injuries trigger systemic inflammation and gut dysfunction.
  • Early enteral feeding is a critical intervention for critically ill patients.
  • The impact of early feeding on gut-specific markers post-burn requires further elucidation.

Purpose of the Study:

  • To investigate the effects of early enteral feeding on gut integrity and inflammatory markers in burn patients.
  • To compare outcomes between early feeding (EF) and delayed feeding (DF) groups.

Main Methods:

  • Randomized controlled trial involving 21 burn patients (mean burn area 45%).
  • Patients were divided into early feeding (EF) and delayed feeding (DF) groups.
  • Plasma endotoxin, MDA, SOD, serum gastrin, plasma motilin, TNF, and IL-8 levels were measured post-burn day (PBD) 4, 8, and 14.

Main Results:

  • EF group showed significantly lower plasma endotoxin and MDA levels compared to DF group (P < 0.05-0.01).
  • Plasma SOD was significantly lower in the DF group on PBD 4 and 8 (P < 0.01).
  • EF group exhibited increased serum gastrin and plasma motilin, with decreased TNF and IL-8 (P < 0.05-0.01).

Conclusions:

  • Early enteral feeding effectively reduces plasma endotoxin levels in burn patients.
  • This intervention mitigates gut reperfusion injury and subsequent mucosal damage.
  • Early feeding helps blunt the inflammatory cascade initiated by endotoxins, improving gut health post-burn.

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