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[Protective role of endogenous nitric oxide to microcirculation of rats during burn shock]
Objective:
To investigate the role of nitric oxide (NO) in burn shock.
Methods:
A model of 40% TBSA deep II burn injury in rats was used. The effects of L-NAME, the inhibitor of NO synthase, and L-Arg, the precursor of NO synthesis, on the mean arterial pressure (MAP), microcirculation of muscle, concentration of NO2(-)/NO3(-) in plasma and the survival time of animals were observed.
Results:
The results showed that the synthesis of nitric oxide was increased significantly, accompanied with the decrease of MAP and the disturbances of microcirculation of muscle after burn. L-NAME inhibited the decrease of MAP, but aggravated the disturbances of microcirculation and shortened the survival time of animals, while L-Arg produced the contrary effects.
Conclusion:
The results indicated that the large amount of NO in blood after burn may play an early protective role to injury.