Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polylactide bioabsorbable polymers for guided tissue regeneration.

R Giardino1, M Fini, N Nicoli Aldini

  • 1Experimental Surgery Department, Rizzoli Orthopaedic Institute, University of Bologna, Italy. giardino@alma.unibo.it

The Journal of Trauma
|August 19, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unlocking diagnosis of sarcopenia: The role of circulating biomarkers - A clinical systematic review.

Mechanisms of ageing and development·2024
Same author

Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta-analysis of clinical outcomes and imaging features.

JOR spine·2024
Same author

Role of bone marrow adipocytes in bone metastasis development and progression: a systematic review.

Frontiers in endocrinology·2023
Same author

Biosynthetic scaffolds for partial meniscal loss: A systematic review from animal models to clinical practice.

Bioactive materials·2021
Same author

The role of subscapularis repair following reverse shoulder arthroplasty: systematic review and meta-analysis.

Archives of orthopaedic and trauma surgery·2021
Same author

Prospects on the Potential In Vitro Regenerative Features of Mechanically Treated-Adipose Tissue for Osteoarthritis Care.

Stem cell reviews and reports·2021
Same journal

Article.

The Journal of trauma·2014
Same journal

Article.

The Journal of trauma·2014
Same journal

Program schedule for the sixty-fifth annual meeting of the american association for the surgery of trauma.

The Journal of trauma·2014
Same journal

Letters to the editor.

The Journal of trauma·2014
Same journal

Posttraumatic brachial plexitis.

The Journal of trauma·2011
Same journal

Incidental findings in focused assessment with sonography for trauma in hemodynamically stable blunt trauma patients: speaking about cost to benefit.

The Journal of trauma·2011
See all related articles

Polylactide conduits promote tissue regeneration. Poly[L-lactide-co-6-caprolactone] (PLLC) conduits aided nerve repair, while poly[DL-lactide] (PDLLA) conduits supported bone growth, showing versatility in biomaterials.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Guided tissue regeneration (GTR) enhances tissue repair by creating optimal environments for intrinsic tissue growth.
  • Developing suitable biomaterials with appropriate physicochemical and biocompatibility properties is crucial for effective GTR devices.

Purpose of the Study:

  • To investigate the efficacy of polylactide-based conduits for guided bone and peripheral nerve regeneration.
  • To evaluate the performance of poly[L-lactide-co-6-caprolactone] (PLLC) for nerve GTR and poly[DL-lactide] (PDLLA) for bone GTR.

Main Methods:

  • Synthesized and chemically characterized two types of polylactide conduits: PLLC for peripheral nerve and PDLLA for bone regeneration.
  • Evaluated the in vivo performance of these conduits in rat sciatic nerve defects and rabbit radius bone defects.

Related Experiment Videos

Main Results:

  • Both PLLC and PDLLA conduits demonstrated excellent biocompatibility.
  • PLLC conduits facilitated significant axonal regeneration and nerve trunk continuity restoration in sciatic nerve gaps.
  • PDLLA conduits effectively shielded bone defects from soft tissue invasion, promoting bone growth across the defect site.

Conclusions:

  • Polylactides exhibit remarkable versatility as biomaterials for guided tissue regeneration applications.
  • These findings support further research into polylactide-based scaffolds for both hard and soft tissue engineering.