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A novel K+ channel blocking toxin from Tityus discrepans scorpion venom
G D'Suze1, F Zamudio, F Gómez-Lagunas
1Laboratory of Cellular Neuropharmacology, Biochemistry and Biophysics Center, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela. gdsuze@ivic.ivic.ve
FEBS Letters
|August 19, 1999
Abstract:
A novel toxin (TdK1) was purified from the venom of the scorpion Tityus discrepans, sequenced and functionally characterized. It contains 37 amino acid residues and blocks reversible the shakerB K+ channel expressed in SF9 cells with a Kd in the order of 280 nM. The proposed systematic nomenclature for this peptide is alpha-KTx4.3.