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Related Experiment Video

Updated: Jun 19, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Monosodium glutamate sensitivity in asthma.

K M Woessner¹, R A Simon, D D Stevenson

¹Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

The Journal of Allergy and Clinical Immunology

|August 19, 1999

Summary

Monosodium glutamate (MSG) ingestion did not trigger asthma attacks in subjects with or without a history of sensitivity. This study suggests a healthy skepticism regarding MSG sensitivity in asthma patients.

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Area of Science:

Clinical immunology
Pulmonary medicine
Food science

Background:

Concerns regarding monosodium glutamate (MSG) and asthma provocation have existed since the 1980s.
Given MSG's widespread use in food, understanding its link to asthma is crucial.

Purpose of the Study:

To investigate if monosodium glutamate (MSG) ingestion can induce asthma attacks in individuals with asthma.

Main Methods:

Single-blind, placebo-controlled challenges were administered to 100 asthma patients (30 with a history of MSG sensitivity, 70 without).
Patients received 2.5g of MSG, and outcomes were monitored, including FEV1 (forced expiratory volume in 1 second).
78 patients were identified as having aspirin-sensitive asthma.

Main Results:

No patient experienced a significant decrease in FEV1 or asthma symptoms during MSG challenge.
Changes in FEV1 did not differ significantly between MSG and placebo challenges across all patient groups.
Confidence intervals indicated a very low probability of MSG sensitivity in both aspirin-sensitive and non-aspirin-sensitive asthma groups.

Conclusions:

MSG challenges did not induce asthma signs or symptoms in participants, regardless of perceived sensitivity.
Previous studies suggesting MSG-induced asthma were poorly conducted and not confirmed by subsequent research.
A skeptical approach is warranted regarding the existence of MSG sensitivity in individuals with asthma.