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Related Experiment Videos

Screening for gynecologic malignancies: A continuing responsibility.

C D Runowicz1, A L Fields

  • 1Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women's Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, USA.

Surgical Oncology Clinics of North America
|August 24, 1999
PubMed
Summary
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Cervical cancer screening with the Papanicolaou test has lowered disease rates. Future efforts focus on reaching unscreened individuals and developing new screening methods for ovarian and endometrial cancers.

Area of Science:

  • Gynecologic Oncology
  • Preventive Medicine
  • Molecular Diagnostics

Background:

  • Papanicolaou (smear) testing significantly reduced cervical cancer incidence and mortality.
  • A critical challenge remains in screening populations currently not undergoing regular cervical cancer screening.
  • Effective screening methods for endometrial and ovarian cancers are currently lacking.

Purpose of the Study:

  • To highlight the success of cervical cancer screening.
  • To identify the need for improved screening in unscreened populations.
  • To explore the potential of molecular genetics for developing novel ovarian cancer screening tools.

Main Methods:

  • Review of existing cervical cancer screening data and outcomes.
  • Analysis of current gaps in gynecologic cancer screening.

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  • Discussion of emerging molecular genetic technologies for cancer detection.

    • Main Results:

    • The Papanicolaou smear has proven effective in reducing cervical cancer.
    • Significant portions of the population remain unscreened for cervical cancer.
    • Molecular genetics holds promise for future ovarian cancer screening development.

    Conclusions:

    • Continued focus on cervical cancer screening outreach is essential.
    • The development of screening modalities for endometrial and ovarian cancers is a critical unmet need.
    • Advances in molecular genetics may offer future solutions for early detection of these gynecologic cancers.