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Mechanistic concepts in androgen-dependence of prostate cancer

N Craft1, C L Sawyers

  • 1Department of Medicine, University of California, Los Angeles, USA.

Cancer Metastasis Reviews
|August 24, 1999
PubMed

Insights

Androgen blockade treats advanced prostate cancer. New models and signaling research reveal androgen receptor changes are key to cancer progression, even to hormone-refractory disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Endocrinology

Background:

  • Androgen blockade is a primary treatment for advanced prostate cancer.
  • Prostate cancer progression involves complex mechanisms of androgen dependence.

Purpose of the Study:

  • To review recent advancements in understanding androgen receptor signaling in prostate cancer.
  • To explore the role of androgen receptor perturbations in disease progression.

Main Methods:

  • Review of current literature on xenograft and transgenic models.
  • Analysis of nuclear receptor signaling pathways.

Main Results:

  • New models provide insights into androgen dependence.
  • Androgen receptor signaling alterations are implicated early in prostate cancer.

Conclusions:

  • Perturbations in androgen receptor signaling are critical for prostate cancer progression.
  • Understanding these mechanisms may lead to improved therapies for hormone-refractory disease.

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