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Intestinal transplantation.

O Goulet1

  • 1Service de Gastroentérologie et Nutrition Pédiatriques, Hôpital Necker-Enfants Malades, Paris, France. olivier.goulet@nck.ap-hop-paris.fr

Current Opinion in Clinical Nutrition and Metabolic Care
|August 24, 1999
PubMed
Summary
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Intestinal transplantation offers an alternative to long-term parenteral nutrition for intestinal failure. Advances in immunosuppression and rejection control make this a viable treatment option for adults and children.

Area of Science:

  • Gastroenterology
  • Transplant Surgery
  • Immunology

Background:

  • Permanent intestinal failure necessitates definitive parenteral nutrition.
  • Parenteral nutrition poses long-term risks and complications.
  • Intestinal transplantation is an emerging alternative treatment.

Purpose of the Study:

  • To review current clinical outcomes of intestinal transplantation.
  • To outline indications for intestinal transplantation.
  • To discuss strategies for managing intestinal transplantation.

Main Methods:

  • Review of recent literature on intestinal transplantation.
  • Analysis of clinical results and patient outcomes.
  • Discussion of immunosuppressive strategies and rejection management.

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Main Results:

  • Intestinal transplantation is increasingly recognized as a standard treatment for intestinal failure.
  • Advances in immunosuppression have improved graft survival and patient outcomes.
  • Successful transplantation is achievable in both adult and pediatric populations.

Conclusions:

  • Intestinal transplantation is a viable alternative to parenteral nutrition for select patients with intestinal failure.
  • Careful patient selection and management of immunosuppression are crucial for success.
  • Further research and standardized protocols will continue to refine this challenging procedure.