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Related Experiment Videos

Neutrophil function in women with pre-eclampsia.

I P Crocker1, R P Wellings, J Fletcher

  • 1The Medical Research Centre, Nottingham University, Nottingham City Hospital NHS Trust, UK.

British Journal of Obstetrics and Gynaecology
|August 24, 1999
PubMed
Summary

Neutrophils in normal pregnancy show reduced reactive oxygen species release. In pre-eclampsia, elevated reactive oxygen generation suggests a role for neutrophils in this condition's oxidative stress and pathophysiology.

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Area of Science:

  • Immunology
  • Obstetrics
  • Pathophysiology

Background:

  • Neutrophils play a crucial role in immune responses.
  • Pregnancy involves significant physiological changes affecting immune function.
  • Pre-eclampsia is a pregnancy complication characterized by hypertension and potential organ damage.

Purpose of the Study:

  • To investigate neutrophil function in normal pregnancy and pre-eclampsia.
  • To compare neutrophil activation and responses between pregnant women with and without pre-eclampsia, and non-pregnant controls.

Main Methods:

  • Peripheral blood neutrophils were analyzed from 16 pre-eclamptic, 17 normal pregnant, and 15 non-pregnant women.
  • Neutrophil responses were measured using agonists like n-formyl-met-leu-phe (fMLP) and zymosan-activated serum.

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  • Assays included superoxide anion production (chemiluminescence), lactoferrin release (ELISA), and cell surface molecule expression (flow cytometry).

    • Main Results:

    • Superoxide anion generation was significantly reduced in normal pregnancy compared to non-pregnant controls.
    • Pre-eclamptic neutrophils did not show this reduction in superoxide anion generation.
    • No significant differences were observed in lactoferrin levels or the expression/release of CD11b, CD18, and L-selectin across the groups.

    Conclusions:

    • Circulating neutrophils are not activated or primed in vivo during normal pregnancy or pre-eclampsia.
    • Diminished reactive oxygen species release occurs in normal pregnancy.
    • Elevated reactive oxygen generation in pre-eclampsia suggests a role for neutrophils in its oxidative stress and pathophysiology.