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Related Experiment Videos

Delayed-onset ticlopidine-induced cholestatic jaundice.

C J Kubin1, O Sherman, K B Hussain

  • 1Department of Pharmacy, Bronx VA Medical Center, New York 10468, USA.

Pharmacotherapy
|August 24, 1999
PubMed
Summary

Ticlopidine therapy can cause delayed jaundice and liver damage in elderly patients, even after drug discontinuation. Early suspicion is crucial for managing potential ticlopidine-induced liver injury.

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Area of Science:

  • Hepatology
  • Clinical Pharmacology

Background:

  • Ticlopidine is an antiplatelet medication.
  • Drug-induced liver injury (DILI) is a significant clinical concern.

Observation:

  • An 86-year-old male developed a rash 2 weeks after initiating ticlopidine.
  • Jaundice and abnormal liver tests appeared 1 month post-discontinuation.
  • These symptoms resolved over several months.

Findings:

  • The case suggests a potential for delayed hepatotoxicity from ticlopidine.
  • The drug's pharmacokinetic profile may contribute to liver damage.
  • Liver test abnormalities indicate hepatocellular injury.

Implications:

  • A high index of suspicion for ticlopidine-induced jaundice is warranted.

Related Experiment Videos

  • Clinicians should monitor liver function in patients exposed to ticlopidine.
  • Prompt recognition and management can improve patient outcomes.