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Rapid onset monoclonal gammopathy in cutaneous lupus erythematosus: interference with complement C3 and C4
M D Larking-Pettigrew1, T P Ranich, R H Kelly
1Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15213-2582, USA.
Immunological Investigations
|August 24, 1999
Abstract:
Accurate nephelometric immunoassay requires both the analyte and the calibration standard to have the same molecular mass. Alteration in the size of the analyte can affect light scatter and yield erroneous results. We report a case where an autoantibody, a monoclonal IgM with immunoconglutinin activity, interfered with the nephelometric quantitation of plasma complement components C3 and C4.