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Related Experiment Videos

Functionally graded fluoridated apatites.

M Okazaki1, Y Miake, H Tohda

  • 1Department of Biomaterials Science, Hiroshima University School of Dentistry, Japan.

Biomaterials
|August 24, 1999
PubMed
Summary
This summary is machine-generated.

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This study synthesized graded fluoridated hydroxyapatite with enhanced acid resistance. The novel gradient fluoride supply method resulted in superior acid resistance compared to previous methods.

Area of Science:

  • Materials Science
  • Biomaterials Science
  • Crystallography

Background:

  • Hydroxyapatite is a key component of teeth and bone.
  • Fluoride incorporation enhances the acid resistance of hydroxyapatite.
  • Previous methods for synthesizing fluoridated hydroxyapatite have limitations in controlling fluoride distribution.

Purpose of the Study:

  • To synthesize fluoridated hydroxyapatite using a gradient fluoride supply system.
  • To characterize the synthesized material's structure, morphology, and fluoride distribution.
  • To evaluate the acid resistance of the synthesized graded fluoridated hydroxyapatite.

Main Methods:

  • Synthesis of fluoridated hydroxyapatite at 80°C and pH 7.4 using a gradient fluoride supply.
  • X-ray diffraction (XRD) for crystallographic analysis.

Related Experiment Videos

  • Scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HRTEM) for morphology and crystal structure.
  • Electron spectroscopy for chemical analysis (ESCA) to determine fluoride concentration gradients.
  • Solubility tests in acetate buffer to assess acid resistance.

    • Main Results:

    • XRD confirmed an apatitic pattern with broader reflections compared to homogeneous fluorapatite.
    • SEM revealed rod-like crystals similar to fluorapatite.
    • HRTEM indicated electron damage in crystal cores.
    • ESCA showed a negative fluoride concentration gradient with depth.
    • The synthesized material exhibited significantly lower solubility (9.16 mmol/l) than homogeneous hydroxyapatite (32.3 mmol/l) and previously synthesized two-layer fluoridated apatite (12.5 mmol/l).

    Conclusions:

    • A graded fluoridated hydroxyapatite with a fluoride concentration gradient was successfully synthesized.
    • This novel synthesis method yields a material with superior acid resistance compared to homogeneous hydroxyapatite and two-layer fluoridated apatite.
    • The findings suggest potential applications in dental materials for enhanced caries prevention.