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Published on: May 31, 2018
Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages
1Molecular Immunology and Immunogenetics Laboratory, Centre for Biochemical Technology, Delhi University Campus, India.
Abstract:
High amounts of nitric oxide and TNF-alpha generated by activated macrophages induce several pathophysiological conditions during acute and chronic inflammation. Identification of new pharmacological reagents that can prevent TNF-alpha and/or NO overproduction is of considerable medical interest. In this report we provide evidence that the overproduction of TNF-alpha and NO by LPS stimulated macrophages can be markedly inhibited by quercetin, a major active component of plant Rhododendron cinnabarium.
