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The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis
W K Chung1, A Luke, R S Cooper
1Columbia University, College of Physicians and Surgeons, Department of Pediatrics, New York, NY 10032, USA.
Abstract:
The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3> have been described in humans, but not in rodents. The functional consequences-or lack thereof-of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.