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Validity of echocardiographic measurement in an epidemiological study. Project HeartBeat!
S Dai1, N A Ayres, R B Harrist
1University of Texas-Houston Health Science Center, School of Public Health, Houston, Texas, USA. sdai@sph.uth.tmc.edu
Insights
Echocardiogram measurements in Project HeartBeat! showed high accuracy and reproducibility in healthy children. This ensures reliable cardiovascular disease risk factor tracking in longitudinal studies.
Area of Science:
- Pediatric Cardiology
- Medical Imaging
- Longitudinal Studies
Background:
- Project HeartBeat! monitors cardiovascular disease risk factors in children and adolescents.
- Echocardiography is crucial for assessing cardiac health in pediatric populations.
- Ensuring measurement accuracy and reproducibility is vital for longitudinal data integrity.
Purpose of the Study:
- To evaluate intraobserver and interobserver variability in echocardiographic measurements.
- To compare field measurements by technicians with reference readings.
- To assess the overall accuracy and reproducibility of echocardiograms in a pediatric cohort.
Main Methods:
- Random selection of 3 echocardiogram samples (40, 80, 182 readings).
- Evaluation of 8 M-mode and 8 Doppler measurements, plus calculated LV mass.
- Statistical analysis of paired measurements to determine bias and random error.
Main Results:
- Intraobserver variability was very small, indicating consistent technician performance.
- Interobserver differences were statistically significant but not clinically relevant for most parameters.
- Comparisons with reference readings showed minimal, clinically insignificant differences.
Conclusions:
- Echocardiographic measurements in healthy children are accurate and reproducible.
- Field echocardiography technicians can obtain reliable data for longitudinal studies.
- Project HeartBeat! data is suitable for tracking cardiovascular health trajectories.
Abstract:
In Project HeartBeat!, a longitudinal study of cardiovascular disease risk factors in healthy children and adolescents, 3 samples of 40, 80, and 182 echocardiograms, respectively, were randomly selected and reread to evaluate intraobserver and interobserver variabilities and comparability between measurements of field echocardiographic technicians and reference readings at Texas Children's Hospital. Included in the evaluation were 8 M-mode echocardiographic measurements, ie, aortic root diameter, left atrial diameter, and end-diastolic and end-systolic measurements of interventricular septal thickness, left ventricular (LV) diameter, and LV posterior wall thickness; 8 Doppler measurements; and a calculated LV mass. Means and SDs of the differences of the paired measurements were used to assess the relative bias and random error of the measurements. For the intraobserver comparison, means and SDs of the differences were very small, indicating that the echo measurements were performed consistently by each project echo technician. Interobserver comparison showed statistically but not clinically significant differences between the paired readings of end-diastolic septal thickness, end-systolic LV posterior wall thickness, and 5 Doppler measurements. Comparison with reference readings at Texas Children's Hospital showed significant differences in diastolic LV diameter, systolic septal thickness, and right ventricular ejection time. These differences, however, were minimal with limited clinical significance. Mean differences in LV mass for the corresponding comparisons were -1.82, 4.50, and 0.0013 g, and the SDs were 18.79, 24.16, and 12.35 g, respectively. We conclude that the echocardiographic measurements taken from healthy children in a longitudinal study can be made accurately with acceptable reproducibility.