Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Magnesium supplementation in Gitelman syndrome.

A Bettinelli1, E Basilico, M G Metta

  • 1Second Department of Pediatrics, University of Milan, Italy.

Pediatric Nephrology (Berlin, Germany)
|August 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring plan quality: using plan complexity to quantitatively analyse the tradeoff between clinical suitability and dosimetric accuracy.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2025
Same author

Breast density prediction model in digital versus synthetic mammograms from a radiomic point of view: A retrospective study.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2025
Same author

Neurological complications of rotavirus infection in children: A systematic review and meta-analysis.

Acta paediatrica (Oslo, Norway : 1992)·2023
Same author

Acute hemorrhagic edema of infancy associated with Coxsackie virus infection.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2018
Same author

Hospital-acquired Legionella infections: an update on the procedures for controlling environmental contamination.

Annali di igiene : medicina preventiva e di comunita·2016
Same author

Lifestyle and food habits changes after migration: a focus on immigrant women in Modena (Italy).

Annali di igiene : medicina preventiva e di comunita·2015
Same journal

Impact of kidney maturation on aminoglycoside exposure in term-born pediatric patients: an in silico study.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Age at onset and cumulative initial prednisolone dose predict frequent relapses in steroid-sensitive nephrotic syndrome: an individual participant data systematic review and meta-analysis of placebo-controlled RCTs.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

"Life renewed, obstacles persist": a systematic review of qualitative studies on the experiences of children and adolescents post-kidney transplantation.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Preemptive rituximab for immunosuppressant withdrawal in adolescents and young adults with childhood-onset steroid-dependent nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Characterizing children with chronic kidney disease and severe proteinuria in the United States: a retrospective analysis using electronic health records.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

New therapeutic hope for rare podocytopathies.

Pediatric nephrology (Berlin, Germany)·2026
See all related articles

Magnesium supplementation improved magnesium and calcium levels in Gitelman syndrome patients but did not fully correct magnesium deficiency or affect potassium levels. This highlights the complex mineral imbalances in this condition.

Area of Science:

  • Renal tubular disorders
  • Mineral and electrolyte metabolism

Background:

  • Gitelman syndrome is characterized by renal magnesium wasting, hypokalemia, and electrolyte disturbances.
  • Magnesium deficiency can impair calcium homeostasis and the function of calciotropic hormones.

Purpose of the Study:

  • To investigate the effects of oral magnesium supplementation on mineral and calciotropic hormone levels in Gitelman syndrome.
  • To assess the efficacy of magnesium pyrrolidone carboxylate in correcting magnesium deficiency and related imbalances.

Main Methods:

  • Eight patients with Gitelman syndrome received oral magnesium pyrrolidone carboxylate (30 mmol/day) for 4 weeks.
  • Plasma and intracellular magnesium, plasma calcium, and calciotropic hormone levels (parathyroid hormone, calcitriol) were measured before and after supplementation.

Related Experiment Videos

  • Plasma and intracellular potassium levels were also monitored.

    • Main Results:

    • Magnesium supplementation significantly increased plasma and intracellular magnesium levels and plasma calcium.
    • Complete correction of magnesium deficiency was not achieved.
    • No significant changes were observed in parathyroid hormone, calcitriol, or plasma and intracellular potassium levels.

    Conclusions:

    • Oral magnesium supplementation can improve magnesium and calcium status in Gitelman syndrome.
    • It does not fully correct magnesium deficiency or normalize potassium levels in this patient group.
    • Further research is needed to understand the long-term effects and optimal management strategies.