Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal urinary acidification in infants with hydronephrosis.

J Chandar1, C Abitbol, M Novak

  • 1Department of Pediatrics, University of Miami School of Medicine/Jackson Memorial Medical Center, FL 33101, USA.

Pediatric Nephrology (Berlin, Germany)
|August 24, 1999
PubMed
Summary

Infants with hydronephrosis show impaired urinary acidification, leading to metabolic acidosis. This defect in net acid excretion affects both unilateral and bilateral cases, highlighting a kidney function issue in dilated urinary tracts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case Report: A rare case of renal failure secondary to in utero megalourethra.

Frontiers in pediatrics·2025
Same author

Corrigendum to 'Partial Bladder Transplantation with En Bloc Kidney Transplant-The First Case Report of a 'Bladder Patch Technique' in a Human' [American Journal of Transplantation 8 (2008) 1060-1063].

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2024
Same author

Umbilical artery histomorphometry: a link between the intrauterine environment and kidney development.

Journal of developmental origins of health and disease·2017
Same author

Understanding c-MET signalling in squamous cell carcinoma of the head & neck.

Critical reviews in oncology/hematology·2017
Same author

Bilateral facial palsy in a child.

European annals of otorhinolaryngology, head and neck diseases·2016
Same author

Search for decays of stopped long-lived particles produced in proton-proton collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Renal Physiology

Background:

  • Dilated urinary tract disorders, including reflux and obstruction, are associated with distal renal tubular abnormalities.
  • Understanding urinary acidification defects is crucial for managing infants with hydronephrosis.

Purpose of the Study:

  • To investigate patterns of urinary acidification in infants with varying degrees of hydronephrosis.
  • To compare acid excretion in infants with hydronephrosis versus controls with secondary metabolic acidosis.

Main Methods:

  • Prospective study of three infant groups: hydronephrosis with acidosis (IA), hydronephrosis without acidosis (IB), and controls with diarrhea (II).
  • Measurements included serum electrolytes, creatinine, urine pH, urinary titratable acidity, ammonium (NH4) excretion, and net acid excretion (NAE) via titrimetry.

Related Experiment Videos

Main Results:

  • Infants with hydronephrosis exhibited reduced urinary buffering capacity and low NAE, even when acidotic.
  • Both titratable acid and NH4 excretion were deficient in hydronephrosis patients compared to controls.
  • Metabolic acidosis occurred similarly in unilateral and bilateral hydronephrosis, irrespective of severity.

Conclusions:

  • Confirms a defect in distal urinary acidification in infants with hydronephrosis (unilateral or bilateral).
  • Infant immaturity and endogenous acid load may contribute to metabolic acidosis in unilateral hydronephrosis.