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Effect of an alpha(2) agonist (mivazerol) on limiting myocardial ischaemia in stable angina
K Fox1, H J Dargie, D P de Bono
1Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, UK.
Abstract:
A specific alpha(2) agonist, mivazerol, known to be effective in reducing myocardial ischaemia when given intravenously immediately before an exercise tolerance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patients with stable angina. A non-significant trend to reduction in electrocardiographic signs of ischaemia was also noted. The clinical relevance of this improvement now needs to be tested in larger numbers.
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