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Massive myelomatous ascites responsive to VAD chemotherapy and autologous stem cell transplantation
A Alegre1, C Martínez-Chamorro, J M Fernández-Rañada
1Haematology Department, Hospital Universitario de la Princesa, Madrid, Spain.
Abstract:
Plasmacytic ascites is an infrequent complication of multiple myeloma. To date, only few cases have been reported with a very rapidly fatal course unresponsive to therapy. We describe a patient with plasmacytic ascites and quiescent multiple myeloma of 8 years of duration. Disease progression became apparent due to myelomatous ascites, unexplained fever, pancytopenia and bone marrow infiltration. This case showed a complete and long-lasting response after VAD chemotherapy followed by autologous PBSC transplantation. Ascites in association with MM may respond for lengthy periods to high-dose chemotherapy and ASCT.