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Related Experiment Videos

Osteoporosis: gender differences and similarities.

S Khosla1, L J Melton, B L Riggs

  • 1Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

Lupus
|August 24, 1999
PubMed
Summary

Estrogen deficiency contributes to bone loss in both women and men. This study suggests estrogen plays a significant role in male bone metabolism, impacting bone mineral density and increasing fracture risk.

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Area of Science:

  • Endocrinology
  • Gerontology
  • Bone Biology

Background:

  • Osteoporosis is traditionally viewed as a women's disease, but men also experience significant age-related bone loss and fractures.
  • Estrogen deficiency is a known cause of bone loss in women (Type I and Type II osteoporosis).
  • The causes of bone loss in aging men have been less clear.

Purpose of the Study:

  • To investigate the role of estrogen in bone loss in aging men.
  • To explore the relationship between estrogen levels and bone mineral density in men.

Main Methods:

  • Review of recent evidence including genetic studies of estrogen receptor-alpha deficiency and aromatase deficiency in men.
  • Analysis of large epidemiologic studies correlating bone mineral density with sex hormone levels in aging men.

Main Results:

  • Evidence suggests estrogen deficiency may significantly impact bone metabolism in men.
  • Bone mineral density in aging men correlates more strongly with serum estrogen levels than testosterone levels.
  • Studies on men with estrogen receptor or aromatase deficiencies indicate estrogen's crucial role in bone health.

Conclusions:

  • Estrogen deficiency is a potential contributor to bone loss in aging men.
  • Further research is warranted to fully understand estrogen's role in male osteoporosis.
  • Findings challenge the traditional view of osteoporosis as solely a postmenopausal women's disease.

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