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Related Experiment Videos

Intact implicit memory for novel patterns in Alzheimer's disease.

B R Postle1, S Corkin, J H Growdon

  • 1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA.

Learning & Memory (Cold Spring Harbor, N.Y.)
|November 1, 1996
PubMed
Summary

Alzheimer's disease (AD) patients show intact implicit memory, specifically pattern priming, despite deficits in explicit memory recognition. This suggests pattern priming relies on the peristriate cortex, not medial temporal lobes.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Repetition priming is implicit memory, independent of the medial temporal-lobe system.
  • Amnesic patient H.M. demonstrates intact priming with novel patterns, indicating nonverbal perceptual priming bypasses explicit memory areas.
  • The peristriate cortex is a potential neural substrate for priming, as it is relatively spared in Alzheimer's disease (AD).

Purpose of the Study:

  • To investigate whether Alzheimer's disease (AD) subjects exhibit intact pattern priming.
  • To determine if pattern priming in AD depends on the peristriate cortex.

Main Methods:

  • Subjects copied target figures onto dot patterns, performed a distractor task, and then redrew figures from memory using the dot patterns.
  • Recognition memory was tested by asking subjects to identify previously copied patterns from multiple choices.

Related Experiment Videos

  • Comparison of priming and explicit memory performance between AD patients and a control group.

    • Main Results:

    • Both AD and control groups showed comparable scores on pattern priming.
    • AD subjects were significantly impaired in explicit memory recognition tasks.
    • Intact pattern priming was observed in AD patients.

    Conclusions:

    • Pattern priming is preserved in Alzheimer's disease (AD).
    • This finding provides the first evidence that pattern priming depends on the peristriate cortex.
    • Implicit memory functions, like pattern priming, may be dissociable from explicit memory deficits in AD.