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New insights into the pathogenesis of interstitial nephritis
1University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia 19104, USA. meyersc@mail.med.upenn.edu
Current Opinion in Nephrology and Hypertension
|August 24, 1999
Abstract:
Emerging data on the role of interstitial inflammation in progressive renal disease are redefining our understanding of the pathogenic mechanisms of chronic kidney damage. Recent experimental evidence emphasizes the role for both immune and non-immune mechanisms in interstitial nephritis. New observations regarding maneuvers that downregulate such injurious renal responses may direct further studies that develop new therapeutic modalities.