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Related Experiment Videos

Keloids have continuous high metabolic activity.

K Ueda1, E Furuya, Y Yasuda

  • 1Department of Plastic and Reconstructive Surgery, Osaka Medical College, Takatasuki City, Japan. pla007@poh.osaka-med.ac.jp

Plastic and Reconstructive Surgery
|August 24, 1999
PubMed
Summary
This summary is machine-generated.

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Keloids and red scars show high adenosine triphosphate (ATP) levels and fibroblast counts. Scar ATP and fibroblast levels decrease over time, unlike persistent high levels in keloids.

Area of Science:

  • Biochemistry
  • Dermatology
  • Wound Healing

Background:

  • Scar tissue formation involves complex cellular and biochemical processes.
  • Adenosine triphosphate (ATP) is a key indicator of cellular metabolic activity.
  • Keloids and hypertrophic scars represent abnormal wound healing with distinct clinical and histological features.

Purpose of the Study:

  • To investigate the relationship between adenosine triphosphate (ATP) levels, fibroblast density, and scar characteristics.
  • To compare ATP content and fibroblast numbers in keloids, hypertrophic scars (red/pink), and atrophic scars (white).
  • To assess the long-term ATP profile in keloids post-injury.

Main Methods:

  • High-performance liquid chromatography (HPLC) was used to quantify ATP content in scar tissues.

Related Experiment Videos

  • Histological analysis with hematoxylin and eosin staining was performed to count fibroblasts and fibrocytes.
  • Spearman's rank correlation was employed to analyze the relationship between ATP levels and time post-trauma.

    • Main Results:

    • Red hypertrophic scars and keloids exhibited significantly higher ATP levels (1.06 mmol/g protein) compared to pink (0.12) and white atrophic scars (0.19).
    • Fibroblast counts were highest in keloids (4.8) and red scars (5.1), decreasing in pink (2.4) and white scars (1.3).
    • ATP levels correlated negatively with time since trauma (r=-0.506, p=0.005), but remained elevated in keloids even after 10 years.

    Conclusions:

    • Keloids and red hypertrophic scars are characterized by elevated ATP levels and increased fibroblast populations.
    • Scar maturation involves a decrease in both ATP content and fibroblast numbers, transitioning from red hypertrophic to white atrophic scars.
    • Keloids demonstrate a sustained high metabolic activity and fibroblast presence long after injury, distinguishing them from other scar types.