Effect of chronic ethanol ingestion on biochemical circadian rhythms in Wistar rats

Chronic ingestion of ethanol for 60 days was known to alter the characteristics of biochemical circadian rhythms in Wistar rats. Peak times of glucose, potassium and lactic acid rhythms were delayed by 18 h, 3 h, and 3 h respectively, whereas peak times of cholesterol and malondialdehyde rhythms were advanced by 3 h and 9 h respectively during ethanol treatment. Significant changes in range (p < 0.001 expect in calcium) and 24 h mean (p < 0.001) of all the biochemical circadian rhythms studied were observed during ethanol treatment. The alterations in the characteristics of these biochemical circadian rhythms could be principally due to the alterations on the hepatic cellular architecture; other plausible underlying reasons are also discussed.