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Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpression of cyclin D1
F Ishida1, K Kitano, N Ichikawa
1Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. fumishi@hsp.md.shinshu-u.ac.jp
Abstract:
We report on a male Japanese patient with hairy cell leukemia (HCL). A cytogenetic study with lipopolysaccharide stimuli showed a novel translocation (11;20)(q13;q11) in 10% of the analyzed cells. Northern blot analysis and RT-PCR analysis for cyclin D1 revealed the overexpression of cyclin D1, although the southern blot analysis of PRAD1 gene showed no rearrangement. In this particular case, the t(11;20)(q13;q11) might play some role in the oncogenesis of HCL and the overexpression of cyclin D1.
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