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Related Experiment Videos

Does desflurane alter left ventricular function when used to control surgical stimulation during aortic surgery?

D Eyraud1, F Benmalek, K Teugels

  • 1Department of Anesthesiology and Intensive Care, Hôpital de la Pitié-Salpêtrière, Paris VI University, France.

Acta Anaesthesiologica Scandinavica
|August 24, 1999
PubMed
Summary

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Desflurane effectively controls intraoperative hypertension during vascular surgery. This anesthetic agent was found to be safe for left ventricular (LV) function in patients at risk for cardiac events.

Area of Science:

  • Anesthesiology
  • Cardiovascular Physiology
  • Surgical Medicine

Background:

  • Intraoperative hypertension is common during vascular surgery.
  • Left ventricular (LV) function effects of desflurane for hypertension control are not well-established.
  • Evaluating desflurane's impact on LV function during this clinical scenario is crucial.

Purpose of the Study:

  • To assess left ventricular (LV) function in response to desflurane administration for controlling intraoperative hypertension.
  • To determine the safety and efficacy of desflurane in managing surgically induced hypertension in patients undergoing vascular surgery.

Main Methods:

  • Fifty patients undergoing vascular surgery were studied.
  • Anesthesia was induced with sufentanil, midazolam, and atracurium, maintained with controlled ventilation.

Related Experiment Videos

  • Transesophageal echocardiography (TEE) and pulmonary artery catheter measurements were taken to assess LV function and hemodynamics before and after desflurane administration for hypertension control.

    • Main Results:

    • Sixteen patients developed intraoperative hypertension at surgical incision.
    • Desflurane successfully controlled hypertension in all affected patients.
    • While afterload markers (SVRI, ESWS, LVSWI) increased, key LV function parameters (cardiac index, stroke volume, fractional area change) remained unchanged, indicating no significant cardiac depressant effect.

    Conclusions:

    • Desflurane is an effective agent for managing intraoperative hypertension in vascular surgery patients.
    • The use of desflurane for hypertension control in this population does not appear to pose a significant risk of cardiac depression.
    • This finding supports the use of desflurane in patients with cardiac comorbidities undergoing vascular procedures.