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Related Experiment Videos

Bullous pemphigoid developing during systemic therapy with chloroquine.

T P Millard1, H R Smith, M M Black

  • 1St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Clinical and Experimental Dermatology
|August 24, 1999
PubMed
Summary

Bullous pemphigoid can be triggered by medications. This case highlights chloroquine as a potential cause, presenting with unusual skin lesions similar to erythema multiforme.

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Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Bullous pemphigoid is an autoimmune blistering disease.
  • Drug-induced bullous pemphigoid is a known but less common presentation.
  • Several medications have been implicated in its development.

Observation:

  • A patient with sarcoidosis developed generalized pruritus and a widespread bullous eruption.
  • The eruption featured acral targetoid lesions, clinically resembling erythema multiforme.
  • The patient was undergoing treatment with chloroquine for sarcoidosis-related dyspnea.

Findings:

  • Histological and immunofluorescence examinations confirmed bullous pemphigoid.
  • The clinical presentation was atypical, with features mimicking erythema multiforme.

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  • Chloroquine was identified as the likely precipitating agent.

    • Implications:

    • This case expands the spectrum of clinical presentations for drug-induced bullous pemphigoid.
    • Highlights the importance of considering chloroquine in the differential diagnosis of drug-induced blistering diseases.
    • Suggests that atypical presentations of bullous pemphigoid may occur with certain drug therapies.