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Related Experiment Videos

Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype.

T Humby1, F M Laird, W Davies

  • 1Department of Neurobiology, The Babraham Institute, Cambridge, UK.

The European Journal of Neuroscience
|August 24, 1999
PubMed
Summary

This study demonstrates operant methods for assessing visuospatial attention in mice. Cholinergic mechanisms are crucial for attention, with genetic factors influencing how these mechanisms affect attentional phenotypes.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Pharmacology

Background:

  • Attentional functioning is critical for cognitive processes.
  • Visuospatial attention is a key component of attention.
  • Understanding the neurobiological basis of attention is essential.

Purpose of the Study:

  • To validate an operant task for assessing visuospatial attentional functioning in mice.
  • To investigate the effects of scopolamine on attentional performance in different mouse strains.
  • To explore the role of cholinergic mechanisms and genotype in attentional processes.

Main Methods:

  • Two hybrid mouse strains (F1 C57Bl/6xDBA/2 and C57Bl/6x129sv) were trained on a five-choice serial reaction time task.
  • Task parameters were systematically manipulated to assess visuospatial attention.

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  • Scopolamine was administered at various doses to evaluate its effects on attentional performance.

    • Main Results:

    • Both mouse strains successfully acquired the task, demonstrating effective attentional functioning.
    • Task manipulations confirmed the assessment of visuospatial attention.
    • Scopolamine produced dose-dependent effects, with specific impacts on discriminative accuracy at lower doses (0.02 and 0.2 mg/kg).
    • The C57Bl/6xDBA/2 hybrid strain showed greater sensitivity to scopolamine.
    • Higher scopolamine doses (2 mg/kg) led to non-specific performance deficits.

    Conclusions:

    • Operant methods, specifically the five-choice serial reaction time task, are effective for assessing visuospatial attention in mice.
    • Cholinergic mechanisms play a significant role in attentional processes across species.
    • Genotype interacts with cholinergic mechanisms to influence the expression of attentional phenotypes.