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Related Experiment Videos

Modulation of immune function by a modified bovine whey protein concentrate.

M L Cross1, H S Gill

  • 1Milk and Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand. M.L.Cross@massey.ac.nz

Immunology and Cell Biology
|August 24, 1999
PubMed
Summary
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Modified whey protein concentrate (mWPC) from cheese production suppresses immune cell proliferation. Enzymatic digestion eliminates this immunomodulatory effect, suggesting potential for developing health-promoting dairy products.

Area of Science:

  • Immunology
  • Food Science
  • Biochemistry

Background:

  • Dairy processing yields by-products with unknown immune effects.
  • Modified whey protein concentrate (mWPC) is a cheese manufacturing by-product.
  • Investigating the immunomodulatory potential of dairy by-products is crucial.

Purpose of the Study:

  • To assess the in vitro immunomodulatory effects of mWPC on murine immune cells.
  • To determine the mechanism by which mWPC affects lymphocyte activation.
  • To evaluate the impact of enzymatic digestion on mWPC's immunomodulatory activity.

Main Methods:

  • In vitro testing of mWPC on murine lymphocytes.
  • Assessing lymphocyte proliferation in response to mitogens and alloantigens.
  • Measuring cytokine secretion and CD25 expression.

Related Experiment Videos

  • Enzymatic digestion of mWPC using pepsin and pancreatin.

    • Main Results:

    • mWPC dose-dependently suppressed T and B lymphocyte proliferation.
    • Suppression occurred during mixed leucocyte reactions but not IL-2-sustained proliferation.
    • mWPC inhibited cytokine secretion and CD25+ T cell blast formation.
    • Pepsin and pancreatin digestion abolished mWPC's immunomodulatory function.

    Conclusions:

    • mWPC inhibits lymphocyte activation, suggesting a role in immune modulation.
    • Enzymatic breakdown negates mWPC's immune-suppressive properties.
    • Dairy by-products like mWPC could be developed into functional foods for health benefits.