Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Endothelial dysfunction and lipid profiles: analysis of the EDO Study].

I Bukovsky1, R Pullmann, M Lang

  • 1Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

Bratislavske Lekarske Listy
|August 24, 1999
PubMed
Summary

High plasma lipids, particularly oxidized ones, impair artery function in middle-aged men. This study links elevated total cholesterol and triglycerides to reduced endothelium-dependent vasodilation, suggesting a key role in atherosclerosis development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recommendations for the Management of Uveitis Associated With Juvenile Idiopathic Arthritis: The Czech and Slovak adaptation of SHARE Initiative.

Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti·2020
Same author

A key-point based real-time tracking of lung tumor in x-ray image sequence by using difference of Gaussians filtering and optical flow.

Physics in medicine and biology·2018
Same author

High loading of polygenic risk in cases with chronic schizophrenia.

Molecular psychiatry·2015
Same author

[Current aspects of therapy conversion for multiple sclerosis].

Der Nervenarzt·2015
Same author

Radiation of the Drosophila nannoptera species group in Mexico.

Journal of evolutionary biology·2015
Same author

Assignment of high-lying bending mode levels in the threshold photoelectron spectrum of NH2: a comparison between pyrolysis and fluorine-atom abstraction radical sources.

Physical chemistry chemical physics : PCCP·2015

Area of Science:

  • Cardiovascular Research
  • Vascular Biology
  • Lipid Metabolism

Background:

  • Endothelial dysfunction is a key factor in atherogenesis.
  • Abnormal serum lipids and lipoprotein oxidation are established atherosclerosis risk factors.
  • Non-invasive methods now allow in vivo assessment of endothelial function and its relation to lipids.

Purpose of the Study:

  • To investigate the influence of plasma lipid levels and lipoprotein oxidation on endothelial function in middle-aged men.
  • To correlate serum lipid profiles and oxidation markers with endothelial function parameters.

Main Methods:

  • High-resolution ultrasound measured radial artery diameter to assess functional and relative vasodilation reserve (FVDR).
  • Blood samples analyzed for total cholesterol (TCH), HDL, triglycerides (Tg), malondialdehyde (MDA), and superoxide dismutase (SOD).

Related Experiment Videos

  • Sixty men aged 25-45 years were studied.

    • Main Results:

    • Negative correlation found between FVDR and TCH (p=0.01), Tg (p=0.002), and TCH/HDL ratio (p=0.015).
    • Positive correlation observed between TCH, Tg, TCH/HDL ratio, and MDA levels (p<0.001).
    • Increased plasma lipids correlated with higher oxidation markers (MDA).

    Conclusions:

    • Elevated plasma lipids are prone to oxidation, contributing to impaired endothelium-dependent vasodilation.
    • Lipoprotein oxidation is a probable mechanism underlying endothelial dysfunction in middle-aged men.
    • Findings highlight the link between lipid metabolism, oxidation, and vascular health.