Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methotrexate nodulosis.

K A Jang1, J H Choi, K C Moon

  • 1Department of Dermatology, University of Ulsan, Seoul, Korea.

The Journal of Dermatology
|August 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A phase 2 randomized controlled trial using biologics to improve multi OIT outcomes (COMBINE): design, rationale, and methods.

Frontiers in allergy·2026
Same author

First Measurement of Missing Energy due to Nuclear Effects in Monoenergetic Neutrino Charged-Current Interactions.

Physical review letters·2025
Same author

Correction to: A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMET<sup>TM</sup> Plus platform.

The pharmacogenomics journal·2024
Same author

Rheological and tribological properties of native potato starch agglomerated by fluidized bed granulator.

International journal of biological macromolecules·2024
Same author

Automated Assessment of the DWI-FLAIR Mismatch in Patients with Acute Ischemic Stroke: Added Value to Routine Clinical Practice.

AJNR. American journal of neuroradiology·2024
Same author

Rheological characteristics of concentrated ternary gum mixtures with xanthan gum, guar gum, and carboxymethyl cellulose: Effect of NaCl, sucrose, pH, and temperature.

International journal of biological macromolecules·2023

Methotrexate (MTX) nodulosis is a recognized side effect in rheumatoid arthritis patients. This case highlights MTX-induced nodulosis in dermatomyositis, suggesting a broader drug-specific phenomenon.

Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Methotrexate (MTX) nodulosis is a known complication in rheumatoid arthritis patients.
  • This phenomenon has not been widely reported in patients treated with MTX for other conditions like dermatological or malignant diseases.
  • The underlying pathophysiology and optimal treatment for MTX nodulosis remain unclear.

Observation:

  • A case of dermatomyositis developed multiple subcutaneous nodules after MTX treatment.
  • Nodules were small, numerous, symmetrical, and grouped on the chest, axillae, upper arms, and thighs.
  • Histopathology of a nodule revealed septal panniculitis.

Findings:

  • MTX nodulosis can occur in patients with dermatomyositis.
  • Discontinuation of MTX and initiation of hydroxychloroquine led to nodule regression.

Related Experiment Videos

  • Histopathological findings indicated septal panniculitis.

    • Implications:

    • MTX nodulosis may be a drug-specific adverse reaction.
    • Awareness is crucial for diagnosing and managing nodule formation in patients on MTX.
    • Hydroxychloroquine may be an effective treatment option for severe cases.