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Published on: March 1, 2015
Third cranial nerve palsy in children
L A Schumacher-Feero1, K W Yoo, F M Solari
1Department of Ophthalmology, University of Pittsburgh School of Medicine, Pennsylvania, USA.
Insights
Pediatric oculomotor (third cranial nerve) palsy often requires surgery for cosmetic alignment, though restoring binocular function is challenging. Amblyopia treatment helps maintain existing visual acuity but rarely improves it.
Area of Science:
- Ophthalmology
- Pediatric Neurology
Background:
- Oculomotor (third cranial nerve) palsy affects eye movement and can lead to cosmetic and functional deficits in children.
- Congenital and acquired causes contribute to the incidence of third cranial nerve palsy in pediatric populations.
Purpose of the Study:
- To investigate the etiologies of third cranial nerve palsy in children.
- To evaluate the sensory, motor, and cosmetic outcomes following treatment for pediatric oculomotor nerve palsy.
Main Methods:
- Retrospective review of clinical records for children diagnosed with third cranial nerve palsy.
- Follow-up data collected from a university-based pediatric ophthalmology practice spanning 1981-1996.
Main Results:
- Partial palsy occurred in 31 children and complete palsy in 18; congenital and trauma were key causes.
- Strabismus surgery significantly improved ocular alignment, with multiple procedures often necessary.
- While cosmetic results were often acceptable, restoration of binocular function and measurable visual acuity improvement were limited.
Conclusions:
- Surgical intervention is frequently required for pediatric third cranial nerve palsy, particularly complete cases.
- Maintaining ocular alignment necessitates multiple strabismus procedures.
- Cosmetic alignment is achievable, but functional recovery, including binocular vision and visual acuity, remains a significant challenge.
Purpose:
To report the causes and the sensory, motor, and cosmetic results after treatment for oculomotor (third cranial nerve) palsy in children.
Methods:
Review of the clinical records of children with a diagnosis of third cranial nerve palsy followed up in a university-based pediatric ophthalmology practice between 1981 and 1996.
Results:
Forty-nine children with 53 affected eyes were followed up for a mean of 5.5 years. Third cranial nerve palsy was partial in 31 children (32 eyes) and complete in 18 children (21 eyes). The palsy was congenital in 20 eyes and caused by postnatal trauma in 17 eyes. Seventeen eyes had aberrant regeneration and four eyes with partial third cranial nerve palsy had spontaneous resolution. Thirty-six children (38 eyes) were affected before visual maturation (age 8 years), and 25 (27 eyes) had amblyopia. Of the five amblyopic eyes with quantifiable visual acuity, none had measurable improvement of Snellen visual acuity during the follow-up period. Overall, visual acuity was between 6/5 and 6/12 at the last follow-up visit in 31 eyes (58%). Ocular alignment was greatly improved after strabismus procedures, with a mean of 1.5 procedures for patients with partial third cranial nerve palsy and 2.3 procedures for those with complete palsy. Binocular function was difficult to preserve or restore but was achieved for some patients with partial third cranial nerve palsy.
Conclusions:
Surgical treatment of third cranial nerve palsy is frequently necessary, especially in cases of complete palsy. Multiple strabismus procedures are often needed to maintain good ocular alignment. Surgery can result in cosmetically acceptable alignment of the eyes, but it rarely results in restoration or achievement of measurable binocular function. Treatment of amblyopia is effective in maintaining the level of visual acuity present at the onset of the third cranial nerve palsy, but improvement in visual acuity is difficult to achieve.
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