Corneal endothelial changes in patients with chronic renal failure
Related Experiment Video
Updated: Oct 19, 2026

Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
Published on: April 24, 2020
N Ohguro1, M Matsuda, M Fukuda
1Department of Ophthalmology, Osaka University Medical School, Suita, Japan. nohguro@ophthal.med.osaka-u.ac.jp
Purpose:
To evaluate the morphologic changes of the corneal endothelium in patients with chronic renal failure.
Methods:
Twenty corneas of 20 patients with chronic renal failure undergoing hemodialysis were examined by wide-field specular microscopy. Twenty normal corneas from 20 healthy age-matched subjects were enrolled as control corneas.
Results:
Despite normal endothelial cell density, the corneal endothelium of patients with chronic renal failure showed marked polymegethism and pleomorphism.
Conclusion:
Polymegethism and pleomorphism of the corneal endothelium are found in patients with chronic renal failure.
Related Concept Videos
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease I: Introduction
Diabetic Nephropathy
Acute Kidney Injury II: Pathophysiology
Chronic Kidney Disease III: Interprofessional Care
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
