Noninfectious crystalline keratopathy after postoperative subconjunctival 5-fluorouracil
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R F Rothman1, J M Liebmann, R Ritch
1Department of Ophthalmology, The New York Eye and Ear Infirmary, New York 10003, USA. rrothman@nyee.edu
Purpose:
To describe a case of transient, noninfectious crystalline keratopathy after postoperative subconjunctival 5-fluorouracil.
Method:
Case report. Slit-lamp biomicroscopic examinations were performed during serial office examinations.
Results:
A 69-year-old woman underwent an uncomplicated trabeculectomy with adjunctive sponge 5-fluorouracil application for 5 minutes in her left eye. Postoperative treatment included topical prednisolone acetate, ciprofloxacin, and scopolamine. She was initially examined with intrastromal corneal crystalline deposits 5 days after her first postoperative subconjunctival injection of 5-fluorouracil. The deposits completely disappeared 4 days later without addition to or change in treatment.
Conclusion:
Transient, noninfectious, crystalline, intrastromal corneal deposits may develop after adjunctive subconjunctival 5-fluorouracil administration.